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ELECTROPHYSIOLOGICAL DIFFERENCES BETWEEN SUBTYPES OF DEMENTIA

Identifieur interne : 002955 ( Main/Exploration ); précédent : 002954; suivant : 002956

ELECTROPHYSIOLOGICAL DIFFERENCES BETWEEN SUBTYPES OF DEMENTIA

Auteurs : Douglas S. Goodin ; Michael J. Aminoff

Source :

RBID : ISTEX:56E7BDD9CDD14709E765C52BF9919D647155A3FA

Abstract

The distinction between subtypes of dementia, in particular between ‘cortical’ and ‘subcortical’ dementias, is controversial. In order to study this we recorded the long latency auditory evoked potential in demented patients with clinically definite Huntington's disease, Parkinson's disease, and Alzheimer's disease We compared the peak latencies of the components of this response both between these groups and with normal subjects, controlling for the effects of age. We found highly significant electrophysiological differences not only between the subcortical group (combined patients with Huntington's and Parkinson's disease) and the cortical group (patients with Alzheimer's disease), but also within the subcortical group itself Using the pattern of electrophysiological response alone, we were able to classify correctly most of our patients using a logistic regression model. These results support the notion that there are distinguishable subtypes of dementia.

Url:
DOI: 10.1093/brain/109.6.1103


Affiliations:


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Le document en format XML

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